When your nerves get damaged—whether from diabetes, shingles, surgery, or an injury—you don’t just feel pain. You feel neuropathic pain, a type of chronic pain caused by faulty nerve signals. Also known as nerve pain, it doesn’t respond to regular painkillers like ibuprofen or acetaminophen. Instead, it screams in burning, shooting, or electric shocks, often without any obvious trigger. This isn’t just discomfort—it’s a misfire in your nervous system, and it needs targeted treatment.
What makes neuropathic pain tricky is that it doesn’t follow the rules of normal pain. You might feel it in your feet even when nothing’s wrong with them, or get sudden jolts from light touch. That’s why doctors reach for meds that weren’t designed for pain at all: anticonvulsants, drugs originally used to stop seizures like gabapentin and pregabalin calm overactive nerves. antidepressants, medications for depression that also affect pain pathways like amitriptyline and duloxetine help too, not because you’re sad, but because they change how your brain processes pain signals. These aren’t quick fixes—they take weeks to work, and side effects like drowsiness or dizziness are common. But for many, they’re the only thing that brings real relief.
There’s no one-size-fits-all solution. What works for one person might do nothing for another. That’s why treatment often involves trial and error, plus lifestyle tweaks—like controlling blood sugar if you have diabetes, or avoiding alcohol that worsens nerve damage. You won’t find a cure in a pill, but you can find control. Below, you’ll find real-world guides on specific drugs, how they interact with other meds, what side effects to watch for, and how to tell if what you’re taking is actually helping—or just adding new problems.
17 November 2025
Gabapentin and pregabalin are top treatments for nerve pain. Learn how they differ in effectiveness, dosing, side effects, and cost to decide which is right for you.
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