Sertraline: What It Is and How It Helps

Sertraline is a commonly prescribed SSRI antidepressant used for major depression, panic disorder, social anxiety, OCD, PTSD, and premenstrual dysphoric disorder (PMDD). It changes brain chemistry to reduce anxiety, lift mood, and lower obsessive thoughts. Many people notice gradual improvement, not an instant fix.

Quick practical facts

Typical adult starting dose is 50 mg once daily, though some doctors begin at 25 mg if side effects are a concern. Usual dose range is 25–200 mg. Expect at least 2–6 weeks to feel real benefit; full effect can take longer. Don’t stop suddenly — taper slowly with your prescriber to avoid withdrawal symptoms like dizziness, irritability, or flu-like feelings.

Common side effects and how to handle them

Nausea, headache, trouble sleeping, tiredness, and sexual problems are the most common side effects. Nausea often gets better after a week or two; taking sertraline with food can help. If it makes you sleepy, try taking it at night; if it wakes you up, take it in the morning. Sexual side effects (lower libido, delayed orgasm) are common — tell your doctor rather than quitting on your own; options include dose changes or switching medications.

Sertraline can cause weight changes for some people. Monitor your weight and talk to your provider if gain or loss is significant. Also watch for increased anxiety or suicidal thoughts, especially in people under 25 — reach out to your prescriber or emergency services if this happens.

People with liver problems usually need lower doses. Routine blood tests aren’t required for most users, but your doctor may check liver enzymes if you have risk factors.

Drug interactions matter. Never combine sertraline with MAO inhibitors (allow about two weeks after stopping an MAOI before starting sertraline). Avoid mixing with other strong serotonergic drugs without medical guidance — the combo can trigger serotonin syndrome, a rare but serious reaction. Also be cautious with blood thinners and NSAIDs — bleeding risk can increase.

Pregnancy and breastfeeding require a careful risk–benefit talk with your doctor. Sertraline is often used during pregnancy when the benefits outweigh the risks, but dose and timing should be individualized. Newborns can have temporary adaptation symptoms if exposed late in pregnancy — your provider will explain what to expect and how to manage it.

Practical tips: keep a simple symptom diary (sleep, mood, side effects) during the first 8–12 weeks; carry a list of all medications and supplements to check for interactions; don’t drink heavily while starting sertraline; and be patient — it takes time to see the full effect.

If you have a history of bipolar disorder, talk to your prescriber before starting sertraline — antidepressants can sometimes trigger mania. Always follow your prescriber’s plan and ask questions if anything feels off.

Want to know more or need help working through side effects? Ask your prescriber or a pharmacist — they can give tailored advice and adjust your treatment safely.